Mårtensson H, Nobin A, Bengmark S, Lunderquist A, Owman T, Sandén G
J Surg Oncol. 1984 Nov;27(3):152-8. doi: 10.1002/jso.2930270305.
Eight patients with metastatic carcinoid tumors and the carcinoid syndrome were treated with gelatin foam embolization of the hepatic arterial tree. The aims were to reduce the tumor mass in the liver and to eliminate the carcinoid syndrome. The effects of the treatment were judged from arteriograms, CT scans, and the levels of serotonin in blood and 5-HIAA in urine, as well as from the clinical symptoms. The mean follow-up time was 12.5 months. In all patients the liver tumor mass was reduced after embolization, and this reduction persisted for at least 6 months in seven patients. After treatment, reduced serotonin levels in blood were measured in four patients and reduced 5-HIAA levels in urine in seven patients. In five patients the carcinoid syndrome disappeared after embolization, but after 6 months two of these five patients had regained symptoms. Adverse reactions were minor consisting of a slight fever, reversibly increased serum levels of liver enzymes, and abdominal pain. In our experience, the hepatic embolization is a simple and safe method of giving relief from the carcinoid syndrome.
八名患有转移性类癌肿瘤和类癌综合征的患者接受了肝动脉树明胶海绵栓塞治疗。目的是减少肝脏中的肿瘤体积并消除类癌综合征。通过动脉造影、CT扫描、血液中血清素水平和尿液中5-羟吲哚乙酸水平以及临床症状来判断治疗效果。平均随访时间为12.5个月。所有患者栓塞后肝脏肿瘤体积均减小，七名患者的这种减小持续至少6个月。治疗后，四名患者血液中血清素水平降低，七名患者尿液中5-羟吲哚乙酸水平降低。五名患者栓塞后类癌综合征消失，但这五名患者中有两名在6个月后症状复发。不良反应轻微，包括轻微发热、血清肝酶水平可逆性升高和腹痛。根据我们的经验，肝栓塞是一种缓解类癌综合征的简单且安全的方法。
