[再生小鼠肝脏中的非典型甲胎蛋白合成细胞]
[Atypical alpha fetoprotein-synthesizing cells in the regenerating mouse liver].
作者信息
Baranov V N, Engel'gardt N V, Lazareva M N, Gusev A I, Iazova A K
出版信息
Biull Eksp Biol Med. 1982 Jul;94(7):82-4.
Ultrastructural localization of alpha-fetoprotein (AFP) was studied with the use of the indirect immunoperoxidase technique in the regenerating liver of three strains of mice after CCl4 poisoning. Upon the use of monoclonal and monospecific antibodies AFP synthesis was revealed in part of mature hepatocytes and in smaller cells. No analogues of small cells were found in the normal liver. It is noted that there is structural similarity of atypical AFP-synthesizing cells to precursor cells of hepatocytes during chemical hepatocancerogenesis in rats. Approaches to identification of atypical cells are discussed.
采用间接免疫过氧化物酶技术，对三种品系小鼠在四氯化碳中毒后再生肝脏中的甲胎蛋白（AFP）进行超微结构定位研究。使用单克隆和单特异性抗体时，在部分成熟肝细胞和较小细胞中发现了AFP合成。在正常肝脏中未发现类似的小细胞。值得注意的是，在大鼠化学性肝癌发生过程中，非典型AFP合成细胞与肝细胞前体细胞存在结构相似性。文中还讨论了鉴定非典型细胞的方法。
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