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[小鼠肝脏再生中甲胎蛋白的合成与定位]

[Synthesis and localization of alpha fetoprotein in liver regeneration in mice].

作者信息

Engel'gardt N V, Poltoranina V S, Lazareva M N, Perova S D, Gleĭberman A S

出版信息

Biull Eksp Biol Med. 1976 Oct;82(10):1251-4.

PMID:70239
Abstract

Typical mature hepatocytes constituting not over several per cent of the total amount of preserved hepatocytes served as the principal site of the alpha-fetoprotein (AFP) localization in the liver of mice regenerating after the CCl4 poisoning or partial hepatectomy. Morphologically they failed to differ from the principal mass of hepatocytes and retained an antigen of the bile capillaries on the surface. A change id to the dynamics of the AFP level in the animal serum. Apparently in regeneration of the mouse liver the principal AFP production was realized by mature hepatocytes.

摘要

典型的成熟肝细胞占保存的肝细胞总量的比例不超过百分之几,是四氯化碳中毒或部分肝切除术后再生小鼠肝脏中甲胎蛋白(AFP)定位的主要部位。从形态学上看,它们与主要的肝细胞团没有区别,并且在表面保留了胆小管的抗原。这一变化与动物血清中AFP水平的动态变化有关。显然,在小鼠肝脏再生过程中,主要的AFP产生是由成熟肝细胞实现的。

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