Ando A, Mori H, Ando I, Hiraki T, Hisada K
Radioisotopes. 1977 Sep;26(9):602-5. doi: 10.3769/radioisotopes.26.9_602.
For purpose of the estimation of the radiation dose to humans from 169Yb-citrate, the whole-body retention studies using five rats were carried out. Following intravenous administration of 169Yb-citrate, the whole-body activity was monitored for 40 days by the animal counter. The whole-body retention curve consisted of three components: the first with a 3.6 hours effective half-time, the second with an 154 hours effective half-time and the third with a 29.9 days effective half-time. Therefore it was assumed that 32% of the administered 169Yb-citrate clears from the kidney with a short biologic half-time (3.6hours), 18% remains in the liver and other soft tissues with a relatively long biologic half-time (194 hours) and 50% remains in the bone with a long biologic half-time (850 days). Based on these biological data and the MIRD Committe method, the average dose to the bone and whole-body were 20.8 rads/mCi and 4.5 rads/mCi respectively.
为了估算柠檬酸镱-169对人体的辐射剂量，使用五只大鼠进行了全身滞留研究。静脉注射柠檬酸镱-169后，用动物计数器对全身放射性活度进行了40天的监测。全身滞留曲线由三个部分组成：第一部分有效半衰期为3.6小时，第二部分有效半衰期为154小时，第三部分有效半衰期为29.9天。因此，假定注入的柠檬酸镱-169中32%以较短的生物半衰期（3.6小时）从肾脏清除，18%以相对较长的生物半衰期（194小时）留在肝脏和其他软组织中，50%以较长的生物半衰期（850天）留在骨骼中。根据这些生物学数据和医学内部辐射剂量委员会的方法，骨骼和全身的平均剂量分别为20.8拉德/毫居里和4.5拉德/毫居里。
