Hiraki T, Ando A, Mori H, Ando I, Sakamoto K, Amano R, Kojima K, Hisada K
Radioisotopes. 1978 Feb;27(2):85-9. doi: 10.3769/radioisotopes.27.2_85.
For the purpose of calculating absorbed dose to humans from 167Tm-citrate, the whole-body retention studies using 5 rats were carried out. Up to 40 days following intravenous injection of 167Tm-citrate, the whole-body counts were monitored with a animal counter. The whole-body retention curve was obtained with three exponentaial components. Namely, the 26% of the injected 167 Tm-citrate had a biological half-time of 3.4 hours, 12.5% had a biological half-time of 99 hours and 61.5% had a biological half-time of 106 days. These results indicate, that three components consist of the rapid clearance from the kidneys, the retention in the liver and other soft tissues with relatively long half-time and the retention in the bones with long half-time. Based on these biological data and the MIRD Committee method, the average dose estimates to the bone and whole-body from intravenous administration of 1 mCi 167Tm-citrate were 7.08 rads and 1.28 rads, respectively.
为了计算柠檬酸铥-167对人体的吸收剂量，使用5只大鼠进行了全身滞留研究。在静脉注射柠檬酸铥-167后的40天内，用动物计数器监测全身计数。全身滞留曲线由三个指数成分组成。具体而言，注射的柠檬酸铥-167中，26%的生物半衰期为3.4小时，12.5%的生物半衰期为99小时，61.5%的生物半衰期为106天。这些结果表明，三个成分包括从肾脏的快速清除、在肝脏和其他软组织中具有相对较长半衰期的滞留以及在骨骼中具有较长半衰期的滞留。基于这些生物学数据和MIRD委员会的方法，静脉注射1毫居里柠檬酸铥-167后，对骨骼和全身的平均剂量估计分别为7.08拉德和1.28拉德。
