Tsianos E B, Jalali M T, Gowenlock A H, Braganza J M
Clin Chim Acta. 1982 Sep 1;124(1):13-21. doi: 10.1016/0009-8981(82)90314-x.
Total serum amylase and its pancreatic (P-type) and salivary (S-type) isoamylase activities were measured in 92 individuals without pancreatic or salivary disease. They were divided into three ethnic sub-groups resident in the UK, namely native Britons, Asians and West Indians. The mean total amylase activity was highest in West Indians (383 U/l), intermediate in Asians (317 U/l) and lowest in Britons (179 U/l). Nine of the 28 Asians and 8 of the 16 West Indians had total amylase activities above the upper end of the reference range for Britons. Such a finding, if accompanied by abdominal symptoms, could lead to exhaustive pancreatic investigation in these ethnic groups unless the appropriate reference range is used. Isoenzyme analysis by inhibitor and electrophoretic techniques indicated that the increase in total amylase was due to increase in S-type isoamylase, P-type isoamylase or both. There was a good correlation between results by the two methods. These differences in serum amylase seem to be genetically determined.
对92名无胰腺或唾液腺疾病的个体测定了血清总淀粉酶及其胰腺型（P型）和唾液腺型（S型）同工淀粉酶活性。他们被分为居住在英国的三个种族亚组，即英国本地人、亚洲人和西印度人。西印度人的平均总淀粉酶活性最高（383 U/l），亚洲人次之（317 U/l），英国人最低（179 U/l）。28名亚洲人中有9人、16名西印度人中有8人的总淀粉酶活性高于英国人参考范围的上限。如果出现腹部症状，这样的结果可能会导致对这些种族群体进行详尽的胰腺检查，除非使用合适的参考范围。通过抑制剂和电泳技术进行的同工酶分析表明，总淀粉酶的升高是由于S型同工淀粉酶、P型同工淀粉酶或两者均升高所致。两种方法的结果之间具有良好的相关性。血清淀粉酶的这些差异似乎是由基因决定的。
