Nenci G G, Berrettini M, Parise P, Agnelli G
Folia Haematol Int Mag Klin Morphol Blutforsch. 1982;109(3):453-63.
A case of systemic mastocytosis with lymphatic, digestive, nervous and bone involvement and with persistent heparinaemia is described. The true heparin nature of the circulating anticoagulant was proved by the conventional titrimetric method with protamine sulphate and by the new specific amidolytic assay of its Xa-inhibiting properties. This human circulating heparin displayed a low specific activity as expressed by its activity/weight ratio.
描述了一例伴有淋巴、消化、神经和骨骼受累且持续存在肝素血症的系统性肥大细胞增多症病例。通过用硫酸鱼精蛋白的传统滴定法及其Xa抑制特性的新特异性酰胺分解测定法，证实了循环抗凝剂的真正肝素性质。这种人体循环肝素以其活性/重量比表示的比活性较低。
