干扰素在自然杀伤细胞杀伤病毒感染靶细胞中的作用。
The role of interferon in the NK cell killing of virus-infected target cells.
作者信息
Anderson M J
出版信息
J Hyg (Lond). 1982 Oct;89(2):347-51. doi: 10.1017/s0022172400070881.
Spleen cells from uninfected CBA mice are more cytotoxic for Sendai virus-infected L929 cells than for uninfected cells and the lymphocytes responsible have the properties of NK cells. Preincubation of spleen cells with culture supernatants from Sendai virus-infected L929 cells increases the cytotoxicity for uninfected target cells. This increase in cytotoxicity can also be produced by pretreatment with purified mouse interferon. The enhancing effect of both the infected culture supernatants and purified interferon can be neutralized with anti-interferon serum. It is concluded that the preferential killing of Sendai virus-infected L929 cells by NK cells is dependent on the induction of interferon and that interferon will increase NK cell cytotoxicity for uninfected target cells.
未感染的CBA小鼠的脾细胞对仙台病毒感染的L929细胞的细胞毒性比对未感染细胞的细胞毒性更强，且起作用的淋巴细胞具有自然杀伤（NK）细胞的特性。将脾细胞与来自仙台病毒感染的L929细胞的培养上清液预孵育，可增加对未感染靶细胞的细胞毒性。用纯化的小鼠干扰素预处理也可产生这种细胞毒性的增加。感染的培养上清液和纯化干扰素的增强作用都可被抗干扰素血清中和。得出的结论是，NK细胞对仙台病毒感染的L929细胞的优先杀伤依赖于干扰素的诱导，并且干扰素会增加NK细胞对未感染靶细胞的细胞毒性。
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