单克隆抗人Ia抗体上的一种复发独特型。
A recurrent idiotype on monoclonal anti-human Ia antibodies.
作者信息
Quaranta V, Zanetti M, Reisfeld R A
出版信息
J Exp Med. 1982 Nov 1;156(5):1551-6. doi: 10.1084/jem.156.5.1551.
We report a recurrent idiotype on a remarkably high fraction (4/19) of murine monoclonal antibodies specific for human Ia monomorphic determinants and elicited by separate immunizations. For three of them, the shared idiotype is associated with the antigen-combining site. These results indicate that the spectrum of mouse antibody responses to human Ia antigens may be based on recurrent idiotypes, suggesting a limited potential repertoire of murine monoclonal antibodies to human Ia antigens. Anti-idiotypic reagents might be helpful in dissecting this repertoire and to generate a mirror image of a human Ia antigenic map. Furthermore, antisera to the idiotype of antibodies specific for human Ia monomorphic determinants might help in elucidating the interactions between Ia molecules and receptors on immune cells.
我们报道了一种独特型，它出现在相当高比例（4/19）的针对人Ia单态决定簇的鼠单克隆抗体中，这些抗体是通过单独免疫诱导产生的。其中三种抗体的共享独特型与抗原结合位点相关。这些结果表明，小鼠对人Ia抗原的抗体反应谱可能基于反复出现的独特型，提示针对人Ia抗原的鼠单克隆抗体的潜在库有限。抗独特型试剂可能有助于剖析这一抗体库，并生成人Ia抗原图谱的镜像。此外，针对人Ia单态决定簇特异性抗体独特型的抗血清可能有助于阐明Ia分子与免疫细胞上受体之间的相互作用。
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