Yoneda S, Ohte N, Samoto T, Kobayashi T, Fudemoto Y, Wada A
Jpn Circ J. 1982 Nov;46(11):1222-6. doi: 10.1253/jcj.46.1222.
Two cases of myocarditis, who had suffered from ventricular extrasystole, leucocytosis and elevated serum enzyme for a long period died from congestive heart failure and/or arrhythmias. The biopsy specimens from the right ventricle in one of them showed a positive reaction against Coxsackie B virus (1, 3, 4 and 5) in the fluorescent antibody method. One case of virus pericarditis had 5 recurrences over a five-year period. He suffered from dyspnea, chest oppression and general fatigue at each recurrence. Cardiomegaly on a chest X-ray, electrocardiographic abnormalities, leucocytosis and elevated serum enzyme appeared. However, serum neutralizing antibody titers against Coxsackie B2 had not risen significantly except during the first attack. Interferon administration inhibited its recurrence successfully.
两例心肌炎患者长期患有室性早搏、白细胞增多和血清酶升高，最终死于充血性心力衰竭和/或心律失常。其中一例患者右心室活检标本采用荧光抗体法检测显示对柯萨奇B病毒（1、3、4和5型）呈阳性反应。一例病毒性心包炎患者在五年内复发了5次。每次复发时，他都会出现呼吸困难、胸闷和全身乏力。胸部X光显示心脏扩大、心电图异常、白细胞增多和血清酶升高。然而，除首次发作外，针对柯萨奇B2的血清中和抗体滴度并未显著升高。使用干扰素成功抑制了其复发。
