Globerson A, Abel L, Barzilay M, Zan-Bar I
Mech Ageing Dev. 1982 Aug;19(4):293-306. doi: 10.1016/0047-6374(82)90013-6.
The status of concanavalin A (Con A)-triggered suppressor cells in aging mice was assessed in relation to untreated cells. Spleen cells of (C3H/ebJ X C57BL/6J)F1 and (BALB/cJ X C57BL/6J)F1 aging (20-41 months' old) and young (2-3 months' old) mice were triggered with Con A and examined for their capacity to suppress lymphocyte proliferative responses elicited by mitogens (Con A and phytohemagglutinin), by mixed lymphocyte reactions or by human gamma-globulin. Con A-triggered cells of the aging mice were found to be less efficient suppressors than those of the young, yet the aging mouse spleen cells exerted a more potent suppressive effect than the young, a priori, without pretreatment. Hence, the immune system in aging is characterized by a change in suppressor cell types; the Con A-triggered suppressors diminish and the naturally occurring, untreated ones become abundant.
研究了衰老小鼠中伴刀豆球蛋白A（Con A）触发的抑制细胞的状态，并与未处理的细胞进行了比较。用Con A刺激（C3H/ebJ×C57BL/6J）F1和（BALB/cJ×C57BL/6J）F1衰老（20 - 41月龄）及年轻（2 - 3月龄）小鼠的脾细胞，检测它们抑制由丝裂原（Con A和植物血凝素）、混合淋巴细胞反应或人γ球蛋白引发的淋巴细胞增殖反应的能力。发现衰老小鼠中Con A触发的细胞作为抑制细胞的效率低于年轻小鼠，但衰老小鼠的脾细胞在未经预处理的情况下，比年轻小鼠的脾细胞具有更强的抑制作用。因此，衰老免疫系统的特征是抑制细胞类型发生变化；Con A触发的抑制细胞减少，而天然存在的、未处理的抑制细胞增多。
