Segal R, Globerson A, Zinger H, Mozes E
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
J Clin Immunol. 1992 Sep;12(5):341-6. doi: 10.1007/BF00920791.
The influence of age on autoimmunity was studied in a model in which experimental systemic lupus erythematosus (SLE) is induced in normal mice by the injection of a human monoclonal anti-DNA antibody expressing a common idiotype designated 16/6 Id. The resulting disease is expressed by the production of a variety of autoantibodies and clinical manifestations characteristic to human SLE. Female BALB/c mice, at ages of 2 and 12 months, were immunized with the 16/6 Id. Mice were tested periodically for the presence of autoantibodies. The production of all autoantibodies tested was significantly lower in the older mice as compared to the group of young mice. Clinical manifestations which included leukopenia, increased erythrocyte sedimentation rate and proteinuria were similar in both age groups. Kidney evaluations revealed differences among the two groups of mice. While in all kidney sections of young mice multiple immune complex deposits were detected, in the group of older mice half had similar pathology while the rest either were negative or had only segmental and partial glomerular immune complex depositions. Thus, aging is associated with a decrease in the capacity to respond to the pathogenic anti-DNA, 16/6 Id, by the production of antibodies and autoantibodies and in the expression of a milder disease.
在一个模型中研究了年龄对自身免疫的影响，该模型通过注射表达一种名为16/6独特型的常见独特型的人单克隆抗DNA抗体，在正常小鼠中诱导实验性系统性红斑狼疮（SLE）。由此产生的疾病表现为产生多种自身抗体以及具有人类SLE特征的临床表现。对2个月和12个月大的雌性BALB/c小鼠用16/6独特型进行免疫。定期检测小鼠是否存在自身抗体。与年轻小鼠组相比，老年小鼠中所有检测的自身抗体的产生均显著降低。两个年龄组的临床表现相似，包括白细胞减少、红细胞沉降率升高和蛋白尿。肾脏评估显示两组小鼠存在差异。在年轻小鼠的所有肾脏切片中均检测到多个免疫复合物沉积，而在老年小鼠组中，一半有类似的病理变化，其余要么为阴性，要么只有节段性和部分肾小球免疫复合物沉积。因此，衰老与产生抗体和自身抗体以响应致病性抗DNA 16/6独特型的能力下降以及较轻疾病的表达有关。
