从cDNA序列推导的加州电鳐乙酰胆碱受体α亚基前体的一级结构
Primary structure of alpha-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence.
作者信息
Noda M, Takahashi H, Tanabe T, Toyosato M, Furutani Y, Hirose T, Asai M, Inayama S, Miyata T, Numa S
出版信息
Nature. 1982 Oct 28;299(5886):793-7. doi: 10.1038/299793a0.
DOI:10.1038/299793a0
PMID:6182472
Abstract
DNA sequences complementary to the Torpedo californica electroplax mRNA coding for the alpha-subunit precursor of the acetylcholine receptor were cloned. The nucleotide sequence of the cloned cDNA indicates that the precursor consists of 461 amino acids including a prepeptide of 24 amino acids. Possible sites for acetylcholine binding and antigenic determinants on the alpha-subunit molecule are discussed.
摘要
克隆了与编码乙酰胆碱受体α亚基前体的加州电鳐电板mRNA互补的DNA序列。克隆的cDNA的核苷酸序列表明，前体由461个氨基酸组成，包括一个24个氨基酸的前肽。讨论了α亚基分子上乙酰胆碱结合的可能位点和抗原决定簇。
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