Holian O, Bombeck C T, Nyhus L M
Agents Actions. 1982 Jul;12(3):268-72. doi: 10.1007/BF01965387.
The effect of IMX on histamine-stimulated gastric secretion has been studied in dogs equipped with gastric cannulas. After determining the histamine dose response, IMX, histamine, and IMX plus histamine were given by a constant intravenous infusion for 3 h, and acid was collected at 15-min intervals. In a separate series of experiments a single dose of 100 mg of db-cAMP was given 1 h after initiation of infusion of IMX, histamine, and histamine plus IMX. Results show that IMX, a potent inhibitor of phosphodiesterase, is a weak stimulant of acid secretion, and augments histamine-stimulated secretion. However, during stimulated acid secretion, there were no significant changes in tissue cAMP levels, Administration of exogenous dib-cAMP did not produce any significant changes in acid secretion in dogs, but did contribute to elevated cAMP levels.
已在装有胃插管的犬中研究了IMX对组胺刺激的胃酸分泌的影响。确定组胺剂量反应后，通过静脉恒速输注给予IMX、组胺以及IMX加组胺3小时，并每隔15分钟收集胃酸。在另一系列实验中，在开始输注IMX、组胺以及组胺加IMX 1小时后给予单剂量100 mg的二丁酰环磷腺苷（db-cAMP）。结果表明，IMX作为一种有效的磷酸二酯酶抑制剂，是胃酸分泌的弱刺激剂，并增强组胺刺激的分泌。然而，在刺激胃酸分泌期间，组织环磷腺苷（cAMP）水平没有显著变化，给予外源性二丁酰环磷腺苷对犬的胃酸分泌没有产生任何显著变化，但确实导致cAMP水平升高。
