Blumenkranz M S, Ophir A, Claflin A J, Hajek A
Am J Ophthalmol. 1982 Oct;94(4):458-67. doi: 10.1016/0002-9394(82)90239-2.
A single intravitreal injection of fluorouracil was effective in the treatment of an experimental model of massive periretinal proliferation. When given with an intravitreal injection of 250,000 heterologous fibroblasts, fluorouracil decreased the rate of tractional retinal detachment from 36.8% in controls (seven of 19 eyes) to 5.2% in treated animals (one of 19 eyes) at one week, and from 73.6% in controls (14 of 19 eyes) to 31.5% in treated animals (six of 19 eyes) after four weeks (P less than .05). Intraocular neovascularization was reduced from 52.6% in controls (ten of 19 eyes) to 5.2% in treated animals (one of 19 eyes) after one week and 36.8% in controls (seven of 19 eyes) to 5.2% in treated animals (one of 19 eyes) after four weeks. When supplemented by repeated 10-mg subconjunctival injections of fluorouracil, or in combination with intravitreally administered indomethacin, this effect appeared to be enhanced. Intravitreal and subconjunctival injections of fluorouracil were well tolerated and may prove to be of significant value in the treatment of human disease.
玻璃体内单次注射氟尿嘧啶对大规模视网膜周增殖的实验模型治疗有效。当与玻璃体内注射250,000个异源成纤维细胞同时给予时，氟尿嘧啶使牵引性视网膜脱离的发生率在1周时从对照组的36.8%（19眼中7眼）降至治疗组动物的5.2%（19眼中1眼），4周后从对照组的73.6%（19眼中14眼）降至治疗组动物的31.5%（19眼中6眼）（P<0.05）。眼内新生血管形成在1周后从对照组的52.6%（19眼中10眼）降至治疗组动物的5.2%（19眼中1眼），4周后从对照组的36.8%（19眼中7眼）降至治疗组动物的5.2%（19眼中1眼）。当辅以10mg氟尿嘧啶结膜下重复注射，或与玻璃体内给予吲哚美辛联合使用时，这种效果似乎会增强。玻璃体内和结膜下注射氟尿嘧啶耐受性良好，可能在人类疾病治疗中具有重要价值。
