新生期给予辣椒素对成年大鼠压力感受器和化学感受器反射的影响。
Influence of neonatally administered capsaicin on baroreceptor and chemoreceptor reflexes in the adult rat.
作者信息
Bond S M, Cervero F, McQueen D S
出版信息
Br J Pharmacol. 1982 Nov;77(3):517-24. doi: 10.1111/j.1476-5381.1982.tb09326.x.
Abstract
1 Baroreceptor and chemoreceptor reflex activity was studied in anaesthetized adult rats which had been treated neonatally with a single injection of capsaicin (50 mg/kg s.c.). 2 Pressor responses to bilateral carotid artery occlusion were significantly lower in capsaicin-treated rats compared with vehicle-treated controls. Pressor responses to intravenously injected noradrenaline were similar in the two groups of rats. 3 Resting respiratory minute volume and tidal volume were lower in anaesthetized capsaicin-treated animals than in vehicle-treated controls, but there was no significant difference in respiratory frequency. 4 The increases in respiration evoked by intravenous administration of the peripheral arterial chemoreceptor stimulant, sodium cyanide, or by breathing a hypoxic gas mixture, were significantly lower in capsaicin-treated rats compared with the controls. 5 It is concluded that baroreceptor and chemoreceptor reflex activity are significantly reduced in anaesthetized adult rats which had been treated neonatally with capsaicin, and that this is likely to result from the destruction of unmyelinated baro- and chemoreceptor afferent fibres.
摘要
- 对新生期单次皮下注射辣椒素（50毫克/千克）的成年麻醉大鼠的压力感受器和化学感受器反射活动进行了研究。2. 与用赋形剂处理的对照组相比，辣椒素处理的大鼠对双侧颈动脉闭塞的升压反应明显更低。两组大鼠对静脉注射去甲肾上腺素的升压反应相似。3. 麻醉状态下，辣椒素处理的动物的静息呼吸分钟量和潮气量低于用赋形剂处理的对照组，但呼吸频率无显著差异。4. 与对照组相比，辣椒素处理的大鼠静脉注射外周动脉化学感受器刺激剂氰化钠或吸入低氧气体混合物引起的呼吸增加明显更低。5. 得出的结论是，新生期用辣椒素处理的成年麻醉大鼠的压力感受器和化学感受器反射活动显著降低，这可能是由于无髓鞘压力感受器和化学感受器传入纤维的破坏所致。
相似文献
1
Influence of neonatally administered capsaicin on baroreceptor and chemoreceptor reflexes in the adult rat.新生期给予辣椒素对成年大鼠压力感受器和化学感受器反射的影响。
Br J Pharmacol. 1982 Nov;77(3):517-24. doi: 10.1111/j.1476-5381.1982.tb09326.x.
2
3
Changes in carotid body amine levels and effects of dopamine on respiration in rats treated neonatally with capsaicin.新生期用辣椒素处理的大鼠颈动脉体胺水平的变化及多巴胺对呼吸的影响。
Br J Pharmacol. 1984 Dec;83(4):909-18. doi: 10.1111/j.1476-5381.1984.tb16531.x.
4
Carotid sinus baroreceptor reflex control of respiration.颈动脉窦压力感受器对呼吸的反射性控制。
Circ Res. 1982 Nov;51(5):624-36. doi: 10.1161/01.res.51.5.624.
5
Ventilatory responses to hypoxia and hypercapnia in awake rats pretreated with capsaicin.辣椒素预处理的清醒大鼠对低氧和高碳酸血症的通气反应。
J Appl Physiol (1985). 1991 Mar;70(3):1168-74. doi: 10.1152/jappl.1991.70.3.1168.
6
Superior laryngeal nerve section abolishes capsaicin evoked chemoreflex in anaesthetized rats.
Acta Neurobiol Exp (Wars). 2002;62(1):19-24. doi: 10.55782/ane-2002-1414.
7
Cardiac sympathetic afferent stimulation augments the arterial chemoreceptor reflex in anesthetized rats.心脏交感传入神经刺激增强麻醉大鼠的动脉化学感受器反射。
J Appl Physiol (1985). 2007 Jan;102(1):37-43. doi: 10.1152/japplphysiol.00681.2006. Epub 2006 Aug 10.
8
Reflex fall in blood pressure mediated by capsaicin-sensitive afferent fibers of the rat splanchnic nerve.
Naunyn Schmiedebergs Arch Pharmacol. 1983 May;322(4):286-9. doi: 10.1007/BF00508344.
9
Effects of acetylcholine and sodium cyanide on cat carotid baroreceptors.乙酰胆碱和氰化钠对猫颈动脉压力感受器的影响。
Br J Pharmacol. 1980 Jul;69(3):433-40. doi: 10.1111/j.1476-5381.1980.tb07032.x.
10
Control of the myocardial contractile state by carotid chemo- and baroreceptor and pulmonary inflation reflexes in conscious dogs.清醒犬中颈动脉化学感受器、压力感受器及肺膨胀反射对心肌收缩状态的控制
J Clin Invest. 1978 Jun;61(6):1593-601. doi: 10.1172/JCI109079.
引用本文的文献
1
TRPV1 Inhibits the Ventilatory Response to Hypoxia in Adult Rats, but Not the CO₂-Drive to Breathe.瞬时感受器电位香草酸亚型1（TRPV1）抑制成年大鼠对低氧的通气反应，但不抑制对二氧化碳的呼吸驱动。
Pharmaceuticals (Basel). 2019 Jan 24;12(1):19. doi: 10.3390/ph12010019.
2
Neonatal capsaicin treatment impairs vasopressin-mediated blood pressure recovery following acute hypotension.新生儿辣椒素治疗会损害急性低血压后血管加压素介导的血压恢复。
Br J Pharmacol. 1984 Feb;81(2):341-5. doi: 10.1111/j.1476-5381.1984.tb10084.x.
3
Changes in carotid body amine levels and effects of dopamine on respiration in rats treated neonatally with capsaicin.新生期用辣椒素处理的大鼠颈动脉体胺水平的变化及多巴胺对呼吸的影响。
Br J Pharmacol. 1984 Dec;83(4):909-18. doi: 10.1111/j.1476-5381.1984.tb16531.x.
4
The effects of neonatal capsaicin treatment on growth and subsequent reproductive function in the rat.新生大鼠辣椒素处理对其生长及后续生殖功能的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Sep;327(3):254-9. doi: 10.1007/BF00502458.
5
Distribution of vasoactive intestinal polypeptide-like immunoreactivity in the mammalian heart. Interrelation with neurotensin- and substance P-like immunoreactive nerves.血管活性肠肽样免疫反应性物质在哺乳动物心脏中的分布。与神经降压素样和P物质样免疫反应性神经的相互关系。
Cell Tissue Res. 1984;236(3):527-40. doi: 10.1007/BF00217219.
6
Evidence for a capsaicin-sensitive vasomotor mechanism in the ventral medullary chemosensitive area of the cat.猫延髓腹侧化学敏感区中辣椒素敏感的血管运动机制的证据。
Naunyn Schmiedebergs Arch Pharmacol. 1985 Mar;329(1):56-62. doi: 10.1007/BF00695193.
7
The influence of neonatal treatment with capsaicin on the control of blood pressure in adult rats in water-replete and water-deprived states.辣椒素对新生大鼠进行处理对处于水分充足和缺水状态的成年大鼠血压控制的影响。
Br J Pharmacol. 1985 Aug;85(4):897-903. doi: 10.1111/j.1476-5381.1985.tb11089.x.
8
Pressor sensitivity to exogenous vasopressin in conscious, adult rats treated neonatally with capsaicin.辣椒素对新生期接受处理的成年清醒大鼠对外源性血管加压素的升压敏感性。
Br J Pharmacol. 1985 May;85(1):115-9. doi: 10.1111/j.1476-5381.1985.tb08837.x.
9
Reflex activation of the adrenal medulla during hypoglycemia and circulatory dysregulations is regulated by capsaicin-sensitive afferents.低血糖和循环调节异常期间肾上腺髓质的反射性激活受辣椒素敏感传入神经的调节。
Naunyn Schmiedebergs Arch Pharmacol. 1988 Sep;338(3):282-6. doi: 10.1007/BF00173401.
10
Arterial chemoreceptor involvement in salicylate-induced hyperventilation in rats.动脉化学感受器参与大鼠水杨酸盐诱导的通气过度。
Br J Pharmacol. 1989 Oct;98(2):413-24. doi: 10.1111/j.1476-5381.1989.tb12612.x.
本文引用的文献
1
An analysis of the primary cardiovascular reflex effects of stimulation of the carotid body chemoreceptors in the dog.犬颈动脉体化学感受器刺激的主要心血管反射效应分析。
J Physiol. 1962 Aug;162(3):555-73. doi: 10.1113/jphysiol.1962.sp006950.
2
Effects of acetylcholine and sodium cyanide on cat carotid baroreceptors.乙酰胆碱和氰化钠对猫颈动脉压力感受器的影响。
Br J Pharmacol. 1980 Jul;69(3):433-40. doi: 10.1111/j.1476-5381.1980.tb07032.x.
3
Neonatal capsaicin and thermal nociception: a paradox.新生儿辣椒素与热痛觉感受：一个悖论。
Brain Res. 1981 Jun 29;215(1-2):414-8. doi: 10.1016/0006-8993(81)90527-8.
4
Neonatal capsaicin does not affect unmyelinated efferent fibers of the autonomic nervous system: functional evidence.新生儿辣椒素不影响自主神经系统的无髓传出纤维：功能证据。
Brain Res. 1982 May 6;239(1):283-8. doi: 10.1016/0006-8993(82)90853-8.
5
Evidence that substance P is a neurotransmitter of baro- and chemoreceptor afferents in nucleus tractus solitarius.P物质是孤束核中压力感受器和化学感受器传入神经的神经递质的证据。
Brain Res. 1980 Jan 13;181(2):476-81. doi: 10.1016/0006-8993(80)90633-2.
6
Substance P: a carotid body peptide.
Neurosci Lett. 1980 Apr;17(1-2):215-9. doi: 10.1016/0304-3940(80)90087-7.
7
Biochemical and anatomical observations on the degeneration of peptide-containing primary afferent neurons after neonatal capsaicin.新生期辣椒素处理后含肽初级传入神经元变性的生化及解剖学观察
Neuroscience. 1981;6(10):1923-34. doi: 10.1016/0306-4522(81)90032-4.
8
Similarities in development of substance P and somatostatin in peripheral sensory neurons: effects of capsaicin and nerve growth factor.外周感觉神经元中P物质和生长抑素发育的相似性：辣椒素和神经生长因子的作用。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4644-7. doi: 10.1073/pnas.78.7.4644.
9
Baroreflex actions of substance P microinjected into the nucleus tractus solitarii in rat: a consequence of local distortion.
Brain Res. 1981 Sep 14;220(2):402-7. doi: 10.1016/0006-8993(81)91233-6.
10
Substance P as a baro- and chemoreceptor afferent neurotransmitter: immunocytochemical and neurochemical evidence in the rat.
Peptides. 1980 Spring;1(1):1-9. doi: 10.1016/0196-9781(80)90027-3.
Zotero 插件