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正常金鱼视网膜中异常的视神经轴突会到达视网膜拓扑视顶盖部位。

Errant optic axons in the normal goldfish retina reach retinotopic tectal sites.

作者信息

Cook J E

出版信息

Brain Res. 1982 Oct 28;250(1):154-8. doi: 10.1016/0006-8993(82)90962-3.

DOI:10.1016/0006-8993(82)90962-3
PMID:6182948
Abstract

Optic axons in the goldfish retina generally run radially from their origins to the optic nerve. However, horseradish peroxidase (HRP), introduced into small groups of axons through lesions in the tecta of normal fish, consistently filled some which ran parallel to the retinal margin for long distances before turning centrally. Since all the HRP-filled ganglion cells lay close together, their axons evidently reached adjacent tectal sites by these widely divergent routes.

摘要

金鱼视网膜中的视神经轴突通常从其起源处径向延伸至视神经。然而,通过正常鱼顶盖的损伤将辣根过氧化物酶(HRP)引入小群轴突中时,总是会填充一些在转向中枢之前沿着视网膜边缘平行延伸很长距离的轴突。由于所有被HRP填充的神经节细胞都紧密排列在一起,它们的轴突显然是通过这些大不相同的路径到达相邻的顶盖部位的。

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Errant optic axons in the normal goldfish retina reach retinotopic tectal sites.正常金鱼视网膜中异常的视神经轴突会到达视网膜拓扑视顶盖部位。
Brain Res. 1982 Oct 28;250(1):154-8. doi: 10.1016/0006-8993(82)90962-3.
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Pathways of regenerated retinotectal axons in goldfish. I. Optic nerve, tract and tectal fascicle layer.金鱼再生视网膜顶盖轴突的通路。I. 视神经、视束和顶盖束层。
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引用本文的文献

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Intraocular Axon Regeneration in a Model of Penetrating Eye Injury.眼内轴突再生在穿透性眼损伤模型中的研究。
J Ocul Pharmacol Ther. 2023 Oct;39(8):563-571. doi: 10.1089/jop.2023.0048. Epub 2023 Jul 24.
2
Growth dynamics and morphology of regenerating optic fibers in tectum are altered by injury conditions: an in vivo imaging study in goldfish.损伤条件改变金鱼视顶盖中再生视神经纤维的生长动力学和形态:一项体内成像研究
Exp Neurol. 2008 Apr;210(2):592-601. doi: 10.1016/j.expneurol.2007.12.006. Epub 2007 Dec 23.
3
Neurolin, the goldfish homolog of DM-GRASP, is involved in retinal axon pathfinding to the optic disk.
神经素,即金鱼体内与DM-GRASP同源的物质,参与视网膜轴突向视盘的寻路过程。
J Neurosci. 1998 May 1;18(9):3363-72. doi: 10.1523/JNEUROSCI.18-09-03363.1998.
4
A pattern of optic axons in the normal goldfish tectum consistent with the caudal migration of optic terminals during development.
Exp Brain Res. 1983;52(1):147-51. doi: 10.1007/BF00237159.