Wall P D, Fitzgerald M
Ciba Found Symp. 1982(91):249-66. doi: 10.1002/9780470720738.ch14.
In the first part of this paper, a series of examples are described where substance P content of afferent C fibres and responses which have been attributed to C fibre excitation vary independently. Thirteen sets of data fail to support the proposal that SP is an excitatory transmitter for noxious inputs. In the second part an alternative hypothesis is proposed in which C fibres would have functions in addition to impulse propagation. It is shown that C fibres are involved in establishing and maintaining the connection between afferent fibres and central cells and that transport mechanisms play a role in this connectivity control. Therefore it is proposed that the chemicals in C fibres should be examined for their possible action on regulatory mechanisms as well as for neurotransmitter action.
在本文的第一部分，描述了一系列实例，其中传入C纤维的P物质含量与归因于C纤维兴奋的反应独立变化。十三组数据未能支持P物质是有害输入的兴奋性递质这一观点。在第二部分中，提出了另一种假说，即C纤维除了脉冲传播外还具有其他功能。结果表明，C纤维参与建立和维持传入纤维与中枢细胞之间的联系，并且转运机制在这种连接控制中发挥作用。因此，建议检查C纤维中的化学物质对调节机制的可能作用以及神经递质作用。
