多系统萎缩中脊髓背角P物质和降钙素基因相关肽显著耗竭，而皮肤潮红反应正常。
Marked depletion of dorsal spinal cord substance P and calcitonin gene-related peptide with intact skin flare responses in multiple system atrophy.
作者信息
Anand P, Bannister R, McGregor G P, Ghatei M A, Mulderry P K, Bloom S R
机构信息
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1988 Feb;51(2):192-6. doi: 10.1136/jnnp.51.2.192.
In view of the presence of neuropeptides in spinal cord autonomic pathways, their regional concentration was studied in post mortem thoracic cord from four cases of multiple system atrophy with progressive autonomic failure (MSA). A marked depletion was observed of substance P, its related peptide substance K, and of calcitonin gene-related peptide (CGRP), particularly in dorsal regions where peptide-containing sensory fibres terminate. As substance P and CGRP in primary sensory fibres are considered mediators of skin flares in Lewis' triple response, histamine-induced skin flares were measured in 12 MSA patients and were found to be preserved. These results provide a new key to the classification and aetiology of autonomic and multiple system degenerations, as well as a model to study the role of sensory neuropeptides in man.
鉴于神经肽存在于脊髓自主神经通路中，对4例伴有进行性自主神经功能衰竭的多系统萎缩（MSA）患者的死后胸段脊髓进行了神经肽区域浓度研究。观察到P物质、其相关肽物质K以及降钙素基因相关肽（CGRP）明显减少，尤其是在含肽感觉纤维终止的背侧区域。由于初级感觉纤维中的P物质和CGRP被认为是Lewis三联反应中皮肤潮红的介质，对12例MSA患者进行了组胺诱导的皮肤潮红测量，发现其得以保留。这些结果为自主神经和多系统变性的分类及病因提供了新的关键线索，同时也为研究感觉神经肽在人体中的作用提供了一个模型。
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