Oehme P, Hecht K, Piesche L, Hilse H, Rathsack R
Ciba Found Symp. 1982(91):296-306. doi: 10.1002/9780470720738.ch17.
Most research on substance P deals with its presumed function in the nervous system. Both excitatory and inhibitory actions have been observed in pharmacological studies. For example, substance P has a dual action on nociception in mice: it produces analgesia or hyperalgesia, depending on the dose and on the individual sensitivity to pain. This is interpreted to mean that substance P is capable of normalizing responsiveness to pain. Thus substance P could be classified as a regulatory peptide, or 'regulide'. A similar normalizing action of substance P was found in stress-induced disorders of sleep, behaviour and blood pressure in rats. The mechanism of this normalizing action is not yet clear. The decrease in activity observed for dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase in adrenal glands of rats treated with the peptide may serve as a preliminary hypothesis.
大多数关于P物质的研究都涉及其在神经系统中假定的功能。在药理学研究中已观察到其兴奋和抑制作用。例如，P物质对小鼠的痛觉有双重作用：根据剂量和个体对疼痛的敏感性，它会产生镇痛或痛觉过敏。这被解释为意味着P物质能够使对疼痛的反应性正常化。因此，P物质可被归类为一种调节肽，或“调节素”。在大鼠因应激引起的睡眠、行为和血压紊乱中也发现了P物质的类似正常化作用。这种正常化作用的机制尚不清楚。在用该肽处理的大鼠肾上腺中观察到的多巴胺β-羟化酶和苯乙醇胺N-甲基转移酶活性的降低可能作为一个初步假设。
