Piesche L, Oehme P, Hilse H, Hecht K
Pharmazie. 1982 Aug;37(8):591-3.
Resulting from literature data concerning interactions between catecholamines and Substance P (SP) the influence of SP on the activity of dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) was studied in rat adrenals. Intraperitoneal application of SP (500 micrograms/kg) to male Wistar rats 15 minutes before decapitation induced a decrease of PNMT activity in the adrenals, while DBH activity remained unchanged. After incubation of adrenals with SP (10(-6) mol/l) a decrease of activity of both PNMT and DBH was observed. The experimental results are discussed in connection with a normalizing function of SP during stress induced disorders.
根据有关儿茶酚胺与P物质（SP）相互作用的文献数据，研究了SP对大鼠肾上腺中多巴胺-β-羟化酶（DBH）和苯乙醇胺-N-甲基转移酶（PNMT）活性的影响。在断头前15分钟给雄性Wistar大鼠腹腔注射SP（500微克/千克），可导致肾上腺中PNMT活性降低，而DBH活性保持不变。用SP（10^(-6)摩尔/升）孵育肾上腺后，观察到PNMT和DBH的活性均降低。结合SP在应激诱导的紊乱中的正常化功能对实验结果进行了讨论。
