Greenwood P D, Brown I R
Neurochem Res. 1982 Aug;7(8):965-76. doi: 10.1007/BF00965136.
Neurons of the rat cerebral hemispheres are known to undergo a postnatal shift to a short DNA repeat length. In the present study we report that rat neuronal nuclei are more sensitive to digestion with DNAse I when isolated at a developmental stage after the shift in neuronal DNA repeated length compared to nuclei isolated before the shift. This observation may suggest that a decondensation of neuronal chromatin accompanies the postnatal shift in DNA repeat length. We have also found that neuronal nuclei isolated after the shift to a short DNA repeat length demonstrate an increased ability to synthesize RNA in vitro.
已知大鼠大脑半球的神经元在出生后会转变为较短的DNA重复长度。在本研究中，我们报告称，与在DNA重复长度转变之前分离的细胞核相比，在神经元DNA重复长度转变后的发育阶段分离的大鼠神经元细胞核对DNA酶I消化更敏感。这一观察结果可能表明，神经元染色质的解聚伴随着出生后DNA重复长度的转变。我们还发现，在转变为短DNA重复长度后分离的神经元细胞核在体外表现出增强的RNA合成能力。
