Loughlin S E, Fallon J H
Neurosci Lett. 1982 Sep 20;32(1):11-6. doi: 10.1016/0304-3940(82)90221-x.
The cells of origin of the brainstem projection to the caudate-putamen (CP) were examined in the albino rat by the use of two fluorescent retrograde tracers. Nuclear yellow was injected into the CP of one hemisphere and granular blue was injected into the contralateral CP. Retrogradely labeled cells were studied in the substantia nigra (SN), ventral tegmental area (VTA) and dorsal raphe (DR). The results confirm previous findings indicating the existence of contralateral projections from SN and VTA to the CP. Cells on both sides of the midline of the DR also project to either CP. Contralaterally projecting SN/VTA cells were located in areas of these nuclei which corresponded to the center of the ipsilaterally projecting cell region; the exact locations depended on the placement of the injection in the CP. In DR, contralaterally projecting cells were most often observed near the midline, although labeled cells were occasionally observed in the lateral wings of the DR. Cells labeled by contralateral injections were interdigitated with, but not identical to, cells labelled by ipsilateral injections. That is, contralaterally projecting cells and ipsilaterally projecting cells constituted separate populations within the SN, VTA and DR.
利用两种荧光逆行示踪剂，在白化大鼠中研究了投射至尾状核-壳核（CP）的脑干细胞起源。将核黄注入一侧半球的CP，将颗粒蓝注入对侧的CP。在黑质（SN）、腹侧被盖区（VTA）和中缝背核（DR）中研究逆行标记的细胞。结果证实了先前的发现，即存在从SN和VTA到CP的对侧投射。DR中线两侧的细胞也投射至任一CP。对侧投射的SN/VTA细胞位于这些核的区域，这些区域与同侧投射细胞区域的中心相对应；确切位置取决于在CP中的注射部位。在DR中，对侧投射细胞最常出现在中线附近，尽管偶尔也在DR的侧翼观察到标记细胞。由对侧注射标记的细胞与同侧注射标记的细胞相互交错，但并不相同。也就是说，对侧投射细胞和同侧投射细胞在SN、VTA和DR中构成了不同的群体。
