Kerr I M, Cayley P J, Silverman R H, Knight M
Philos Trans R Soc Lond B Biol Sci. 1982 Sep 24;299(1094):59-67. doi: 10.1098/rstb.1982.0106.
On interferon treatment cells develop an antiviral state. This requires time and RNA and protein synthesis. At least six polypeptides and two enzymes have been reported to be synthesized in increased amounts in response to interferon and a multiplicity of effects have been attributed to it. Interferon has been reported to inhibit virus growth at the level of the uncoating of the virus, virus RNA and protein synthesis and virus maturation. This has led to the acceptance of a multisite model for interferon action. The evidence for this and for the role of two known interferon-mediated enzymes, the 2-5A synthetase and protein kinase, are reviewed.
在干扰素治疗下，细胞会形成抗病毒状态。这需要时间以及RNA和蛋白质合成。据报道，至少有六种多肽和两种酶在受到干扰素刺激后合成量增加，并且人们认为它具有多种作用。据报道，干扰素在病毒脱壳、病毒RNA和蛋白质合成以及病毒成熟水平上抑制病毒生长。这导致人们接受了干扰素作用的多位点模型。本文综述了这方面的证据以及两种已知的干扰素介导酶，即2-5A合成酶和蛋白激酶的作用。
