Gobien R P, Valicenti J F, Paris B S, Daniell C
Radiology. 1982 Dec;145(3):603-5. doi: 10.1148/radiology.145.3.6183707.
A total of 164 consecutive patients were studied prospectively in the hope of increasing the accuracy of a negative prediction of transthoracic thin-needle biopsy. The protocol included pre-biopsy imaging with conventional and computed tomography, repeated sampling if no malignant cells were found, and specialized staining and culture methods. Forty-four patients with no evidence of malignant cells were divided into "benign specific" [25] and "benign nonspecific" groups [19]. A variety of bacterial and fungal infections, benign tumors, and other benign specific diagnoses were made. The accuracy of a negative prediction for the benign specific group was found to be 1.00 (100%), while that for the benign nonspecific group varied from 84% to 95% depending on whether the 2 patients lost to follow-up had benign disease.
我们前瞻性地研究了连续164例患者，以期提高经胸细针穿刺活检阴性预测的准确性。研究方案包括活检前采用传统成像和计算机断层扫描，若未发现恶性细胞则重复采样，以及采用特殊染色和培养方法。44例无恶性细胞证据的患者被分为“良性特异性”组[25例]和“良性非特异性”组[19例]。诊断出了多种细菌和真菌感染、良性肿瘤及其他良性特异性疾病。结果发现，良性特异性组阴性预测的准确性为1.00（100%），而良性非特异性组的准确性则在84%至95%之间，这取决于失访的2例患者是否患有良性疾病。
