Private specificity of H-2Ldx molecule detected serologically by a surface antigen redistribution method (capping).

The presence of H-2.1 positive-H-2.63 negative molecules, H-2Ldx, in the products of the Ddx region was originally detected in H-2dx inbred strains GRS/A and LIS/A (Snoek et al. 1979). This study confirms the existence of H-2Ldx molecules in 2 congeneic strains with a H-2dx haplotype on C3H (C3H.LG strain) and B10 (B10.GR strain) background. Besides anti-H-2.1-like antibodies present in anti-Ddx allo-antiserum, monoclonal antibody d anti-k (H100-5/28, H-2.m3) was shown to react with H-2Ldx molecule. Furthermore, evidence is shown that H-2Ldx molecule has a unique specificity, which is detected serologically in a capping experiment.