[磷酸聚雌二醇治疗转移性前列腺癌中的甲状腺激素]
[Thyroid hormones in metastasizing prostate cancer treated with polyestradiol phosphate].
作者信息
Dunzendorfer U, Schulz H
出版信息
Z Urol Nephrol. 1982 Jul;75(7):493-500.
PMID:6183845
Abstract
Patients with prostate cancer demonstrate a significant change in thyroid hormones when treated with estrogens after orchiectomy. Low-dose estrogen treatment for more than six months stimulates the synthesis of thyroxine-binding globulin. As a consequence, serum level of thyroxine is also increased. Serum free thyroxine is distinctly lowered by estrogen treatment while the linear ratio of thyroxine and free thyroxine is disturbed.
摘要
前列腺癌患者在睾丸切除术后接受雌激素治疗时，甲状腺激素会发生显著变化。低剂量雌激素治疗超过六个月会刺激甲状腺素结合球蛋白的合成。因此，血清甲状腺素水平也会升高。雌激素治疗会使血清游离甲状腺素明显降低，同时甲状腺素与游离甲状腺素的线性比例受到干扰。
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