Roberts A J, Cipriano P R, Alonso D R, Jacbostein J G, Combes J R, Gay W A
Circulation. 1978 Jan;57(1):35-41. doi: 10.1161/01.cir.57.1.35.
Several invasive and noninvasive techniques used in determining the size of experimental myocardial infarction were evaluated after acute ligation of the left anterior descending (LAD) coronary artery in ten dogs. Systemic blood pressure, left ventricular end-diastolic pressure (LVEDP), and heart rate did not change significantly for up to 24 hours after coronary occlusion. Left ventricular wall motion abnormalities were detected by left ventriculography in the distribution of the LAD but these changes did not correlate well with the infarct weight determined at autopsy. On the other hand, the number of epicardial sites with ST-segment elevation of greater than or equal to 2 mm (mean 15.1 sites +/- 0.6 SEM) and the infarct area as measured by 99mTc-glucoheptonate (TcGH) myocardial imaging (15.7 sq cm +/- 0.6) did correlate strongly with the infarct weight (16.8 g +/- 0.7) determined by the nitroblue tetrazolium (NBT) technique (r = 0.91). TcGH myocardial scintigraphy and epicardial ST-segment mapping allowed early and accurate quantification of experimental myocardial infarcts ranging from less than 1 g to 28 g.
在十只狗身上急性结扎左冠状动脉前降支（LAD）后，对几种用于测定实验性心肌梗死面积的有创和无创技术进行了评估。冠状动脉闭塞后长达24小时内，全身血压、左心室舒张末期压力（LVEDP）和心率均无显著变化。通过左心室造影在LAD分布区域检测到左心室壁运动异常，但这些变化与尸检时确定的梗死重量相关性不佳。另一方面，ST段抬高大于或等于2毫米的心外膜部位数量（平均15.1个部位±0.6标准误）以及通过99m锝-葡庚糖酸盐（TcGH）心肌显像测量的梗死面积（15.7平方厘米±0.6）与通过硝基四氮唑蓝（NBT）技术确定的梗死重量（16.8克±0.7）密切相关（r = 0.91）。TcGH心肌闪烁显像和心外膜ST段标测能够早期且准确地量化范围从小于1克到28克的实验性心肌梗死。
