Gorizontova M P, Shinkarenko V S, Chernukh A M
Biull Eksp Biol Med. 1982 Sep;94(9):15-8.
The experiments have been made on rats with the use of animals' immobilization on the back during 1 or 24 h as a stressor. Intravital study of the microcirculation in the rat mesentery has shown that P substance in a concentration of 7 X 10(-8) M aggravated the disturbances caused by the immobilization, while antiserum to P substance with an activity of 150 ng SP/equiv. normalized the microcirculation. The action of P substance and antiserum was similar as regards disturbances of vascular permeability for colloid carbon particles. It is concluded that P substance participates in the mechanisms of microcirculatory and vascular permeability disturbances during stress.
以大鼠为实验对象，采用将动物背部固定1或24小时作为应激源。对大鼠肠系膜微循环的活体研究表明，浓度为7×10(-8)M的P物质会加剧固定引起的紊乱，而活性为150 ng SP/当量的P物质抗血清可使微循环恢复正常。就胶体碳颗粒的血管通透性紊乱而言，P物质和抗血清的作用相似。得出的结论是，P物质参与应激过程中微循环和血管通透性紊乱的机制。
