Gorizontova M P, Odariuk Iu, Binert M
Biull Eksp Biol Med. 1988 Apr;105(4):403-5.
Biomicroscopic experiments have shown that the N-terminal fragment of substance P (SP1-4), when applied to the rat mesentery, has a considerably lower injuring effect than substance P (SP1-11) itself. SP1-4 activity, as compared to SP1-11 activity regarded as 1, was 0.007 in case of microcirculatory disturbances and venular permeability increase and 0.0007 in case of mast cell degranulation increase. The data obtained suggest that the slightest damaging effect of SP1-4 on microcirculation is combined with anti-stress activity.
生物显微镜实验表明，当将P物质的N端片段（SP1 - 4）应用于大鼠肠系膜时，其损伤作用远低于P物质（SP1 - 11）本身。与被视为1的SP1 - 11活性相比，在微循环紊乱和小静脉通透性增加的情况下，SP1 - 4的活性为0.007；在肥大细胞脱颗粒增加的情况下，其活性为0.0007。所获得的数据表明，SP1 - 4对微循环的微小损伤作用与抗应激活性相关。
