肉桂水提取物（CCAq）的免疫药理学研究。I. 抗过敏作用。

Immunopharmacological studies of the aqueous extract of Cinnamomum cassia (CCAq). I. Anti-allergic action.

作者信息

Nagai H, Shimazawa T, Matsuura N, Koda A

出版信息

Jpn J Pharmacol. 1982 Oct;32(5):813-22. doi: 10.1254/jjp.32.813.

DOI:10.1254/jjp.32.813

Abstract

Effect of the aqueous extract of Cinnamomum Cassia (CCAq) on experimental allergic reaction was investigated. IgE mediated reactions, homologous passive cutaneous anaphylaxis (PCA), degranulation of mast cells, and the release of histamine from sensitized lung tissues classified as the type I reaction by Coombs and Gell were not affected by CCAq. Complement dependent reactions including reversed cutaneous anaphylaxis (RCA), Forssman cutaneous vasculitis (FCV), and nephrotoxic serum (NTS) nephritis classified as type II and the Arthus reaction classified as type III were clearly inhibited by CCAq. However, CCAq did not affect the nephritis caused by the F(ab')2 portion of the nephrotoxic IgG antibody. CCAq in a high concentration inhibited the immunological hemolysis, chemotactic migration of neutrophils in response to complement activated serum, and the generation of chemotactic factors. The type IV reaction, contact dermatitis, was not affected by CCAq. The production of hemolytic plaque forming cells was slightly inhibited by CCAq. These results suggest that CCAq has an anticomplement action and inhibits the complement dependent allergic reaction.

摘要

研究了肉桂水提取物（CCAq）对实验性过敏反应的影响。IgE介导的反应、同源被动皮肤过敏反应（PCA）、肥大细胞脱颗粒以及致敏肺组织中组胺的释放（这些被库姆斯和盖尔分类为I型反应）不受CCAq影响。补体依赖性反应，包括反向皮肤过敏反应（RCA）、福斯曼皮肤血管炎（FCV）和肾毒性血清（NTS）肾炎（分类为II型）以及阿蒂斯反应（分类为III型）均被CCAq明显抑制。然而，CCAq对肾毒性IgG抗体的F（ab'）2部分引起的肾炎没有影响。高浓度的CCAq抑制免疫性溶血、中性粒细胞对补体激活血清的趋化性迁移以及趋化因子的产生。IV型反应，即接触性皮炎，不受CCAq影响。溶血空斑形成细胞的产生受到CCAq的轻微抑制。这些结果表明，CCAq具有抗补体作用，并抑制补体依赖性过敏反应。