脱髓鞘性神经病与抗髓鞘相关糖蛋白单克隆IgM抗体

Demyelinating neuropathy and monoclonal IgM antibody to myelin-associated glycoprotein.

作者信息

Steck A J, Murray N, Meier C, Page N, Perruisseau G

出版信息

Neurology. 1983 Jan;33(1):19-23. doi: 10.1212/wnl.33.1.19.

DOI:10.1212/wnl.33.1.19

Abstract

We studied a patient with demyelinating neuropathy and monoclonal IgM kappa antibody to the major myelin-associated glycoprotein (MAG). Binding of this monoclonal antibody to the myelin antigen was demonstrated by immunoelectroblot. Binding to MAG seemed to be specific, because it was completely inhibited by MAG isolated from human myelin. Immunostaining was observed with MAG from CNS and peripheral nervous system myelin.

摘要

我们研究了一名患有脱髓鞘性神经病且针对主要髓鞘相关糖蛋白（MAG）的单克隆IgM κ抗体的患者。通过免疫印迹法证实了这种单克隆抗体与髓鞘抗原的结合。与MAG的结合似乎具有特异性，因为它被从人髓鞘中分离出的MAG完全抑制。在中枢神经系统和周围神经系统髓鞘的MAG上观察到免疫染色。