Melmed C, Frail D, Duncan I, Braun P, Danoff D, Finlayson M, Stewart J
Neurology. 1983 Nov;33(11):1397-405. doi: 10.1212/wnl.33.11.1397.
Three patients with a monoclonal IgM kappa paraproteinemia had a slowly progressive segmental demyelinating peripheral neuropathy. Sural nerve biopsies showed predominantly large fiber loss, with widening of the intraperiod line of myelin associated with active demyelination. Immunoblot analysis showed reactivity of IgM to myelin-associated glycoprotein (MAG) of human myelin. An enzyme-linked immunosorbent assay (ELISA) was developed to provide a simple quantitative technique for detection of antibodies to MAG. Treatment with corticosteroids, immunosuppressive agents, and plasmapheresis produced no significant improvement.
三名患有单克隆IgM κ副蛋白血症的患者出现了缓慢进展的节段性脱髓鞘性周围神经病。腓肠神经活检显示主要为大纤维丢失，伴有与活动性脱髓鞘相关的髓鞘内周期线增宽。免疫印迹分析显示IgM与人髓鞘的髓鞘相关糖蛋白（MAG）有反应性。开发了一种酶联免疫吸附测定（ELISA）以提供一种简单的定量技术来检测抗MAG抗体。使用皮质类固醇、免疫抑制剂和血浆置换治疗均未产生明显改善。
