Popov T, Zaprianov Z, Benchev I, Spasovski M
Probl Khig. 1982;7:68-75.
Two series of studies were carried out: I--in workers exposed to four different mean annual CS2 concentrations--6 mg/m3; 12 mg/m3; 51 mg/m3 and 247 mg/m3 and II series-in workers exposed to three styrene concentrations--I mg/m3; 40 mg/m3 and 400 mg/m3. The results obtained in series I show the role of the primary toxic effect (inhibition of oxidases with mixed function) and of the adaptation reactions to it with a view to accurate specifying the threshold of chronic CS2 effect. The mathematical expression of the correlation between styrene concentration in air and blood, of phenyl-glyoxylic and mandelic acid in the urine of the exposed subjects enables the prognosis that the threshold of the noxious styrene effect is within the range of 150 mg/m3 to 250 mg/m3. A reduction on CS2 MAC is proposed--from 10 mg/m3 to I mg/m3 and the correction of styrene MAC--from 5 mg/m3 to 30-50 mg/m3.
第一组——针对暴露于四种不同年均二硫化碳浓度（6毫克/立方米、12毫克/立方米、51毫克/立方米和247毫克/立方米）的工人；第二组——针对暴露于三种苯乙烯浓度（1毫克/立方米、40毫克/立方米和400毫克/立方米）的工人。第一组研究结果显示了主要毒性作用（抑制混合功能氧化酶）及其适应性反应的作用，以便准确确定慢性二硫化碳效应的阈值。暴露受试者尿液中苯乙烯浓度与血液中苯乙烯浓度以及苯乙醇酸和扁桃酸之间相关性的数学表达式表明，有害苯乙烯效应的阈值在150毫克/立方米至250毫克/立方米范围内。建议将二硫化碳的最高容许浓度从10毫克/立方米降至1毫克/立方米，并将苯乙烯的最高容许浓度从5毫克/立方米校正至30 - 50毫克/立方米。
