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一种豆类α淀粉酶抑制剂制剂(淀粉阻滞剂)对人体无效。

A bean alpha-amylase inhibitor formulation (starch blocker) is ineffective in man.

作者信息

Carlson G L, Li B U, Bass P, Olsen W A

出版信息

Science. 1983 Jan 28;219(4583):393-5. doi: 10.1126/science.6184780.

DOI:10.1126/science.6184780
PMID:6184780
Abstract

A commercial alpha-amylase inhibitor with potent inhibitory activity in vitro was used in a randomized double-blind, cross-over clinical trial in six nonobese, healthy adult males. In these subjects, this inhibitor had no effect on the response of blood glucose, insulin, or breath hydrogen to a standardized starch meal. It is concluded that this formulation has no effect on starch digestion in humans.

摘要

一种在体外具有强大抑制活性的商业α-淀粉酶抑制剂,被用于一项针对6名非肥胖健康成年男性的随机双盲交叉临床试验。在这些受试者中,该抑制剂对标准化淀粉餐引起的血糖、胰岛素或呼气氢反应没有影响。得出的结论是,该制剂对人类淀粉消化没有影响。

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1
A bean alpha-amylase inhibitor formulation (starch blocker) is ineffective in man.一种豆类α淀粉酶抑制剂制剂(淀粉阻滞剂)对人体无效。
Science. 1983 Jan 28;219(4583):393-5. doi: 10.1126/science.6184780.
2
Effects of a commercial starch blocker preparation on carbohydrate digestion and absorption: in vivo and in vitro studies.
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Effect of trestatin, a new inhibitor of pancreatic alpha-amylase, on starch metabolism in man.
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Gastrointestinal and metabolic effects of amylase inhibition in diabetics.淀粉酶抑制对糖尿病患者胃肠道及代谢的影响
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引用本文的文献

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2
Heterologous expression of an α-amylase inhibitor from common bean (Phaseolus vulgaris) in Kluyveromyces lactis and Saccharomyces cerevisiae.菜豆(Phaseolus vulgaris)α-淀粉酶抑制剂在乳酸克鲁维酵母和酿酒酵母中的异源表达。
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Susceptibility of sweet potato (Ipomoea batatas) peel proteins to digestive enzymes.
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The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents.脂质和碳水化合物消化酶抑制剂在肥胖管理中的作用:当前和新兴治疗药物的综述。
Diabetes Metab Syndr Obes. 2010 May 10;3:125-43. doi: 10.2147/dmsott.s7005.
6
Bean alpha-amylase inhibitor 1 in transgenic peas (Pisum sativum) provides complete protection from pea weevil (Bruchus pisorum) under field conditions.转基因豌豆(Pisum sativum)中的菜豆α-淀粉酶抑制剂1在田间条件下能为豌豆象(Bruchus pisorum)提供完全保护。
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3820-5. doi: 10.1073/pnas.070054597.
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alpha-amylase inhibitor increases plasma 3-hydroxybutyric acid in food-restricted rats.α-淀粉酶抑制剂可增加限食大鼠的血浆3-羟基丁酸水平。
Experientia. 1995 Jun 14;51(6):585-8. doi: 10.1007/BF02128748.
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Commercial soybean starch blocker consumption: impact on weight gain and on copper, lead and zinc status of rats.食用商业大豆淀粉阻滞剂:对大鼠体重增加以及铜、铅和锌状态的影响。
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