纯化蝎毒素（巴西矛头蝮毒素）对大鼠胰腺分泌的影响。

Effect of purified scorpion toxin (tityustoxin) on the pancreatic secretion of the rat.

作者信息

Novaes G, Catanzaro O L, Beraldo W T, Freire-Maia L

出版信息

Toxicon. 1982;20(5):847-53. doi: 10.1016/0041-0101(82)90072-1.

Abstract

Intravenous injection, in anesthetized rats, of a single dose of purified scorpion toxin (tityustoxin, TsTX), obtained from the venom of the Brazilian scorpion Tityus serrulatus, causes a striking increase in flow rate, protein content, kallikrein and amylase activities of the pancreatic juice. The flow rate and protein content of the juice remain significantly higher than in control rats, for at least one hour, whereas the kallikrein activity returns to control values 30 min after tityustoxin injection. Sub-diaphragmatic bilateral vagotomy does not prevent the pancreatic secretion induced by tityustoxin; moreover, vagotomy potentiates the flow rate and kallikrein secretion produced by the toxin. Pre-treatment of the rats with atropine blocks the pancreatic secretion evoked by tityustoxin. It is suggested that the pancreatic secretion induced by tityustoxin is due to actions of acetylcholine, released from postganglionic nerve fibers, on muscarinic receptors. The mechanism by which vagotomy potentiates the pancreatic secretion evoked by tityustoxin is under investigation.

摘要

给麻醉大鼠静脉注射单剂量从巴西蝎子锯齿蝎毒液中提取的纯化蝎毒素（蒂尤斯毒素，TsTX），会使胰液的流速、蛋白质含量、激肽释放酶和淀粉酶活性显著增加。胰液的流速和蛋白质含量至少在一小时内仍显著高于对照大鼠，而激肽释放酶活性在注射蒂尤斯毒素30分钟后恢复到对照值。膈下双侧迷走神经切断术并不能阻止蒂尤斯毒素诱导的胰腺分泌；此外，迷走神经切断术会增强毒素产生的流速和激肽释放酶分泌。用阿托品预处理大鼠可阻断蒂尤斯毒素诱发的胰腺分泌。提示蒂尤斯毒素诱导的胰腺分泌是由于节后神经纤维释放的乙酰胆碱作用于毒蕈碱受体所致。迷走神经切断术增强蒂尤斯毒素诱发的胰腺分泌的机制正在研究中。