Novaes G, Cabral A P, de Falco C N, de Queiroz A C
Arq Gastroenterol. 1989 Jan-Jun;26(1-2):9-12.
The toxin produced by the Brazilian scorpion Tityrus serrulatus (Tityustoxin) promotes pancreatitis when injected into dogs and rats. The aim of this study is to analyse the histological picture of the rat pancreas at different time intervals after tityustoxin administration. Male adult Wistar rats, weighing 250 +/- 30 g, received i.v. injections of tityustoxin. Different groups were sacrificed after 10, 20 and 40 minutes and after 24 and 96 hours. In all groups the pancreas was removed and examined under light microscope. Results show specific lesions after TsTX administration. After 10, 20 and 40 minutes histological sections of the pancreas showed degeneration with degranulation. After 24 and 96 hours a characteristic picture of acute pancreatitis was evident. Since cellular damage to the pancreas is evident soon after TxTX injection, we suggest a direct action of the venom on this organ. Furthermore, based on these findings, it is possible to claim for a rapid onset of the management of patients offended by scorpion stings.
巴西蝎子锯齿蒂氏蝎产生的毒素（蒂氏毒素）注入狗和大鼠体内时会引发胰腺炎。本研究的目的是分析给予蒂氏毒素后不同时间间隔大鼠胰腺的组织学情况。体重为250±30克的成年雄性Wistar大鼠接受静脉注射蒂氏毒素。在10分钟、20分钟、40分钟以及24小时和96小时后处死不同组的大鼠。所有组均取出胰腺并在光学显微镜下检查。结果显示给予蒂氏毒素后出现了特定病变。在10分钟、20分钟和40分钟时，胰腺组织切片显示有脱颗粒变性。在24小时和96小时后，急性胰腺炎的典型表现明显。由于在注射蒂氏毒素后不久胰腺细胞损伤就很明显，我们认为毒液对该器官有直接作用。此外，基于这些发现，可以主张对蝎子蜇伤患者迅速展开治疗。
