Leistner K, Wessel G
Z Gesamte Inn Med. 1982 Oct 1;37(19):627-32.
In accordance with the prevailing trends of the development of science in rheumatology Wright, Moll and Haslock inaugurated the integrative conception of the seronegative spondarthritides in the middle of the seventies. The diseases which belong to the seronegative spondarthritides are the ankylosing spondylitis, the psoriasis-arthritis, the Reiter syndrome, the Behçet syndrome, the ulcerous colitis, Crohn's disease and Whipple's disease. Object of the representation is the determination of the notion of seronegative spondarthritis and its presence among the dwelling population. Furthermore, the authors deal more in detail with the distribution according to the demographic and ethnographic characteristics, the frequency of the presence of HLA B 27 as well as with the results of familial investigations (familial aggregation and association). The heuristic value of the classification scheme of the seronegative spondarthritides developed by clinics appears worth of discussion, since from the epidemiological point of view aggravating critical objections concerning the method must be raised. Clinico-epidemiological statements of investigation, prospective and multicentric longitudinal investigations concerning the more profound study of the "natural history" of the seronegative spondarthritides are hopeful and necessary within the future research strategy.
按照风湿病学领域科学发展的主流趋势，赖特、莫尔和哈斯洛克在70年代中期开创了血清阴性脊柱关节炎的综合概念。属于血清阴性脊柱关节炎的疾病包括强直性脊柱炎、银屑病关节炎、赖特综合征、白塞综合征、溃疡性结肠炎、克罗恩病和惠普尔病。本报告的目的是确定血清阴性脊柱关节炎的概念及其在常住人口中的存在情况。此外，作者更详细地探讨了根据人口统计学和人种学特征的分布情况、HLA B27的出现频率以及家族研究的结果（家族聚集性和关联性）。临床所制定的血清阴性脊柱关节炎分类方案的启发价值似乎值得探讨，因为从流行病学角度来看，必须对该方法提出严重的批判性异议。在未来的研究策略中，进行有关血清阴性脊柱关节炎“自然史”更深入研究的临床流行病学调查陈述、前瞻性和多中心纵向研究是有希望且必要的。
