Landolfi R, Scabbia E, Accorrà F, Cudillo L, Tanzi P, Schiavoni G, Bizzi B
Acta Cardiol. 1982;37(5):325-32.
Beta-thromboglobulin (beta TG) plasma levels were measured by radioimmunoassay in 14 patients with acute myocardial infarction (MI), in 13 with myocardial ischemia and recurrent episodes of angina and in 14 subjects with a past history of MI. Increased beta TG plasma values were observed in patients with acute MI and with myocardial ischemia whereas subjects with a past history of MI showed results not significantly different from normal subjects. Daily measurements in acute MI showed in five cases a second peak of beta TG values which suggests the occurrence of a deep vein thrombosis. The increased platelet consumption in MI was not related with the extent of the necrosis. We suggest, therefore, that platelet activation is associated with myocardial ischemia rather than necrosis.
采用放射免疫分析法测定了14例急性心肌梗死（MI）患者、13例心肌缺血伴心绞痛反复发作患者以及14例有MI病史患者的血浆β-血小板球蛋白（βTG）水平。急性MI患者和心肌缺血患者的血浆βTG值升高，而有MI病史的患者其结果与正常受试者无显著差异。急性MI患者的每日测量结果显示，5例患者出现βTG值的第二个峰值，这提示发生了深静脉血栓形成。MI中血小板消耗的增加与坏死程度无关。因此，我们认为血小板活化与心肌缺血而非坏死有关。
