Kubisz P, Parizek M, Seghier F, Holan J, Cronberg S
Atherosclerosis. 1985 Jun;55(3):363-8. doi: 10.1016/0021-9150(85)90114-5.
The incidence of second wave of platelet aggregation induced by a small dose of ADP (1 mumol/l) was compared with plasma levels of beta-thromboglobulin in 81 normal individuals, 34 patients with acute myocardial infarction, 11 patients with acute cerebrovascular disease and 26 patients with renal disease. Platelet hyperaggregability was observed in 7% of normal individuals. Plasma levels of beta-thromboglobulin were higher in normal individuals over 60 years of age (48 vs. 32 micrograms/l). In contrast, hyperaggregability was observed in 79% of patients with acute myocardial infarction and in 64% of those with acute cerebrovascular disease. Median plasma levels of beta-thromboglobulin were also significantly elevated in patients with acute myocardial infarction (82 micrograms/ml) or acute cerebrovascular disease (99 micrograms/l). Levels of beta-thromboglobulin in plasma were significantly higher in those patients who demonstrated hyperaggregability. In patients with renal disease only 12% had signs of hyperaggregability. Nevertheless their plasma levels of beta-thromboglobulin were elevated (76 micrograms/l) and correlated with the serum creatinine values. These investigations indicate that patients with acute myocardial infarction or stroke have hyperreactive platelets and evidence of increased platelet inactivation in the circulation. However, evaluation of increased levels of beta-thromboglobulin requires consideration of renal function.
将81名正常个体、34名急性心肌梗死患者、11名急性脑血管疾病患者和26名肾脏疾病患者小剂量ADP（1微摩尔/升）诱导的第二波血小板聚集发生率与血浆β-血小板球蛋白水平进行比较。7%的正常个体观察到血小板高聚集性。60岁以上正常个体的血浆β-血小板球蛋白水平较高（48对32微克/升）。相比之下，79%的急性心肌梗死患者和64%的急性脑血管疾病患者观察到高聚集性。急性心肌梗死患者（82微克/毫升）或急性脑血管疾病患者（99微克/升）的血浆β-血小板球蛋白中位数水平也显著升高。表现出高聚集性的患者血浆中β-血小板球蛋白水平显著更高。在肾脏疾病患者中，只有12%有高聚集性迹象。然而，他们的血浆β-血小板球蛋白水平升高（76微克/升），并与血清肌酐值相关。这些研究表明，急性心肌梗死或中风患者的血小板反应性过高，且有循环中血小板失活增加的证据。然而，评估β-血小板球蛋白水平升高需要考虑肾功能。
