Rewerski W, Misterek K, Dorociak A, Gumułka S W
Acta Physiol Pol. 1982 May-Jun;33(3):185-8.
Effects of substance P (SP) administered into anterior hypothalamus or lateral ventricle on body temperature were investigated. When administered into lateral ventricle in doses from 20 to 2000 ng SP failed to influence body temperature. Application of SP into anterior hypothalamus in the same doses (20-2000 ng) resulted in a mild but insignificant increase in body temperature. No visible changes in the behavior of the rats, except slight sedation after the highest dose administered into lateral ventricle, were observed after application of SP. These results suggest that SP does not play any essential role in thermoregulation.
研究了将P物质（SP）注入下丘脑前部或侧脑室对体温的影响。当以20至2000纳克的剂量注入侧脑室时，SP未能影响体温。以相同剂量（20 - 2000纳克）将SP注入下丘脑前部导致体温有轻微但不显著的升高。注入SP后，除了向侧脑室注入最高剂量后有轻微镇静作用外，未观察到大鼠行为有明显变化。这些结果表明，SP在体温调节中不发挥任何重要作用。
