Dietz R, Burger L, Schimrigk K, Merkel K H
Acta Neurochir (Wien). 1982;65(3-4):167-73. doi: 10.1007/BF01405842.
The combination of chemotherapy and irradiation for the treatment of malignant intracerebral tumours is increasing, and survival times longer than those after monotherapy are reported. The suitability of simultaneous radio-chemotherapy using BCNU-Bleomycin, a regimen in which has been followed 38 patients of this hospital (up to 31 December 1981) is critically discussed. Statistics of 30 patients with treatment ended by 31 December 1980 and case histories of two patients with fatal complications, aspergillosis in the one and necrotizing colitis in the other, are presented. The value of the various agents used for chemotherapy is discussed with respect to the survival rates and observed side effects in all the patients. The use of Bleomycin is questioned.
化疗与放疗联合用于治疗恶性脑肿瘤的情况日益增多，且有报告称其生存时间比单一疗法更长。本文对使用卡莫司汀-博来霉素进行同步放化疗的适用性进行了批判性讨论，本院有38例患者采用了该方案（截至1981年12月31日）。文中呈现了截至1980年12月31日治疗结束的30例患者的统计数据以及两名出现致命并发症患者的病历，其中一例为曲霉菌病，另一例为坏死性结肠炎。针对所有患者的生存率和观察到的副作用，讨论了用于化疗的各种药物的价值。对博来霉素的使用提出了质疑。
