Peterson T V, Felts F T, Chase N L
Am J Physiol. 1983 Jan;244(1):H55-9. doi: 10.1152/ajpheart.1983.244.1.H55.
Experiments were performed in anesthetized Macaca fascicularis monkeys to determine the effects of combined thoracic dorsal rhizotomy (C8-T7) and vagotomy-sinoaortic denervation on the renal responses to acute intravascular volume expansion. Expansion of the estimated blood volume by 15% with 6% dextran in isotonic saline produced attenuated diuretic and natriuretic responses in the denervated animals when compared with sham-operated controls. The times to peak diuresis and natriuresis after volume expansion also were significantly earlier in the denervated group. Although central venous pressure increased similarly in both groups, mean arterial pressure increased to a greater extent after volume expansion in the denervated group. As opposed to the previously reported failure of either denervation alone to attenuate the renal responses to hypervolemia in the monkey, our results suggest that these neural pathways may play a role in maintaining salt and water balance in this species. However, because of the possibility of functionally redundant afferent mechanisms, blunted renal responses to volume expansion in the primate can only be demonstrated after an extensive denervation.
在麻醉的食蟹猴身上进行实验，以确定胸段背根切断术（C8 - T7）联合迷走神经切断术 - 窦主动脉去神经支配对肾脏对急性血管内容量扩张反应的影响。与假手术对照组相比，用等渗盐水中的6%右旋糖酐将估计血容量扩充15%时，去神经支配的动物利尿和排钠反应减弱。去神经支配组容量扩张后达到利尿和排钠峰值的时间也明显更早。虽然两组中心静脉压的升高相似，但去神经支配组容量扩张后平均动脉压升高幅度更大。与之前报道的单独去神经支配均未能减弱猴子对血容量过多的肾脏反应不同，我们的结果表明，这些神经通路可能在维持该物种的盐和水平衡中起作用。然而，由于存在功能冗余传入机制的可能性，只有在广泛去神经支配后，才能证明灵长类动物对容量扩张的肾脏反应减弱。
