Wüst H J, Fiedler H W, Trobisch H, Richter O
Anaesthesist. 1982 Oct;31(10):564-74.
In 51 patients undergoing either implantation of an aortofemoral bypass (38 patients) or of an saphenous bypass (13 patients) the fibrinolytic and complement system profiles were determined. During the course of an aortofemoral bypass the plasminogen concentration decreased by 40%, alpha 2-macroglobulin by 25%, the complement factor C3c by 20% and the complement factor C4 by 40%. Antithrombin III concentration remained stable until the third postoperative day. The alpha 1-antitrypsin concentration increased postoperatively by 40% compared to the preoperative control. The concentrations of plasminogen, antithrombin III, alpha 2-macroglobulin and complement factor C4 did not change in the patients undergoing saphenous bypass operation. Intraoperatively the complement factor C3c decreased by 20%, while alpha 1-antitrypsin showed postoperatively an increase by 30%. Anaesthesia (neuroleptanaesthesia, halothane- or continuous thoracal epidural anaesthesia) had no influence on the fibrinolytic and complement system profiles. Neither could a correlation be shown between the intraoperative haemodynamic changes and the concentrations of the factors of the fibrinolytic and complement system.
在51例接受主动脉股动脉旁路移植术（38例）或大隐静脉旁路移植术（13例）的患者中，测定了纤溶和补体系统指标。在主动脉股动脉旁路移植术过程中，纤溶酶原浓度下降40%，α2-巨球蛋白下降25%，补体因子C3c下降20%，补体因子C4下降40%。抗凝血酶III浓度在术后第三天前保持稳定。与术前对照相比，α1-抗胰蛋白酶浓度术后升高40%。接受大隐静脉旁路移植术的患者中，纤溶酶原、抗凝血酶III、α2-巨球蛋白和补体因子C4的浓度没有变化。术中补体因子C3c下降20%，而α1-抗胰蛋白酶术后升高30%。麻醉（神经安定麻醉、氟烷或连续胸段硬膜外麻醉）对纤溶和补体系统指标没有影响。术中血流动力学变化与纤溶和补体系统因子浓度之间也没有相关性。
