Izumi A K, Takiguchi P
Arch Dermatol. 1983 Jan;119(1):61-4.
A young woman had a history of subcutaneous nodules, migratory arthralgia, myalgia, and lymphadenopathy. Histopathologic characteristics of the nodular subcutaneous lesion showed a massive lobular panniculitis characteristic of lupus erythematosus (LE) panniculitis. The diagnosis of LE panniculitis was established by demonstration of a positive linear basement membrane zone stain of the involved skin by direct immunofluorescence microscopy. Initial serologic findings showed negative antinuclear antibody (ANA) and anti-DNA antibody test results and a negative LE cell preparation. Subsequently, a positive ANA test result developed. The test result for extractable nuclear antigen was strongly positive, although initial test results for antibodies to ribonucleoprotein and Sm antigens were negative.
一名年轻女性有皮下结节、游走性关节痛、肌痛和淋巴结病病史。结节性皮下病变的组织病理学特征显示为狼疮性脂膜炎（LE脂膜炎）典型的大片小叶性脂膜炎。通过直接免疫荧光显微镜检查发现受累皮肤的线性基底膜带染色呈阳性，从而确诊为LE脂膜炎。最初的血清学检查结果显示抗核抗体（ANA）和抗DNA抗体检测结果为阴性，LE细胞检查结果也为阴性。随后，ANA检测结果转为阳性。可提取核抗原检测结果呈强阳性，尽管最初针对核糖核蛋白和Sm抗原的抗体检测结果为阴性。
