Linkie D M
J Recept Res. 1981;2(5-6):487-501. doi: 10.3109/107998981809038881.
Previous studies in immature rodents have demonstrated the presence of two forms (4S, 5S) of salt extractable estrogen receptor in uterine nuclear preparations. The link between these binding forms appears to be that of hormone dependence and time in a precursor-product relationship. In the present study, this relationship has been observed in nuclear extracts of the uterus and anterior pituitary of intact and gonadectomized adult rats. Both forms of the estrogen receptor have also been isolated from purified nuclei of endometrial cell preparations of the adult dog. As a result of these studies, the phenomenon of intranuclear receptor transformation in estrogen action may now be extended to include (a) the physiologic state of adulthood, (b) persist in the absence of endogenous estrogens and (c) be a feature of estrogen target tissues in animal species other than rodents.
先前对未成熟啮齿动物的研究表明，子宫核提取物中存在两种形式（4S、5S）的盐溶性雌激素受体。这些结合形式之间的联系似乎是激素依赖性和前体-产物关系中的时间关系。在本研究中，在完整和去势成年大鼠的子宫和垂体前叶核提取物中观察到了这种关系。两种形式的雌激素受体也已从成年犬子宫内膜细胞制备物的纯化核中分离出来。这些研究的结果表明，雌激素作用中核内受体转化现象现在可能扩展到包括：（a）成年生理状态，（b）在内源性雌激素缺乏的情况下持续存在，以及（c）是啮齿动物以外的其他动物物种中雌激素靶组织的一个特征。
