FMRF酰胺对软体动物心脏的抑制伴随着环磷酸腺苷（cAMP）的增加。

FMRFamide inhibition of a molluscan heart is accompanied by increases in cyclic AMP.

作者信息

Painter S D

出版信息

Neuropeptides. 1982 Oct;3(1):19-27. doi: 10.1016/0143-4179(82)90062-2.

Abstract

The molluscan neuropeptide FMRFamide (Phe-Met-Arg-Phe-NH2) inhibits the beat of isolated ventricles of the freshwater clam Lampsilis claibornensis. The decline in frequency and diastolic tone precedes the dose- and time-dependent increase in cAMP also produced by the peptide. Phosphodiesterase inhibitors (theophylline, 3-isobutyl-1-methylxanthine) and cAMP analogs also inhibit Lampsilis hearts, but only at high doses (10(-5)-10(-3)M). Again, the inhibition by theophylline is accompanied by a rise in cAMP. Nevertheless, the delayed increase in cAMP levels following FMRFamide treatment may suggest that cAMP is not mediating the onset of FMRFamide cardioinhibition.

摘要

软体动物的神经肽FMRF酰胺（苯丙氨酸-甲硫氨酸-精氨酸-苯丙氨酸-NH2）可抑制淡水蛤蜊克莱伯恩灯蛤分离心室的搏动。频率和舒张期张力的下降先于该肽引起的cAMP呈剂量和时间依赖性增加。磷酸二酯酶抑制剂（茶碱、3-异丁基-1-甲基黄嘌呤）和cAMP类似物也能抑制灯蛤心脏，但仅在高剂量（10⁻⁵ - 10⁻³M）时有效。同样，茶碱的抑制作用伴随着cAMP的升高。然而，FMRF酰胺处理后cAMP水平的延迟升高可能表明cAMP并非介导FMRF酰胺心脏抑制作用的起始因素。