[Effects on exocrine pancreatic secretion in swine of the prolonged intravenous administration of glucose: application to the study of dietary adaptation mechanisms].

The effects of intravenous glucose perfusion were studied in the pancreatic juice of fistulated pigs. Perfusions were performed either discontinuously for 3 hrs in the fasted or for 6 hrs a day over 6 days in the fed animal. Pancreatic juice volume, total proteins and total activities of chymotrypsin, amylase and lipase were always significantly lowered by glucose given intravenously. Amylase seemed to be the most inhibited of the three enzymes studied. It appeared that prolonged intravenous glucose perfusion could not reproduce in the pig the pancreatic amylase adaptation seen after oral administration of glucose.