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[博来霉素对不同部位鳞状上皮的差异作用]

[Differential effect of bleomycin on squamous epithelium at various sites].

作者信息

Bürkle V, Bürkle G, Zielke R

出版信息

HNO. 1982 Dec;30(12):462-6.

PMID:6186652
Abstract

By autoradiographic methods it was examined, whether a specific local effect on squamous epithelium can be proved in a animal model. For this purpose the proliferatory activity was considered in the epithelium of the murine tongue, of esophagus, of the skin in the area of foot and of tail as long as 72 hours after a single application of bleomycin. The result shows, that the proliferatory activity is impaired to a greater extent in the epithelium of the tongue and the esophagus in comparison on the squamous epithelium of foot and tail skin.

摘要

通过放射自显影方法,研究了在动物模型中是否能证明对鳞状上皮有特定的局部影响。为此,在单次应用博来霉素后长达72小时内,观察了小鼠舌头、食管、足部和尾部皮肤区域上皮的增殖活性。结果表明,与足部和尾部皮肤的鳞状上皮相比,舌头和食管上皮的增殖活性受到的损害更大。

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