Dobrokhotov V N, Valvas V S, Vasil'eva V I, Ivanova L N, Kudriavtseva A S
Biull Eksp Biol Med. 1980 Apr;89(4):483-5.
Significant retardation of cell entering the division cycle before prophase was recorded in the tongue epithelium and exocrine cells of the pancreas after colchamine injection (4 mg/kg) to mice. The retardation occurs rather in the evening and night hours. Almost complete supression of cell entering mitosis and presumably delayed course of cell division were observed in liver parenchymal cells as a result of colchamine injection at the same hours. The data obtained call in question the feasibility of the colchamine method for determining mitosis duration in bodily tissues.
给小鼠注射秋水仙碱（4毫克/千克）后，在舌上皮和胰腺外分泌细胞中记录到细胞在前期之前进入分裂周期明显延迟。这种延迟多发生在傍晚和夜间。在相同时间注射秋水仙碱后，在肝实质细胞中观察到几乎完全抑制细胞进入有丝分裂，并且推测细胞分裂过程延迟。所获得的数据使人对秋水仙碱法测定身体组织中有丝分裂持续时间的可行性产生质疑。
